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Ions: The Body's Electrical
Energy Source
Mark T. Nielsen
Professor, Department of Biology
University of Utah
Energy is an important factor in the function
of our bodies. We often say, "I am lacking energy" or
"I wish I had more energy." But, what is energy? Simply
defined, energy is the capacity to do work, or to place matter
into motion. It is the use of energy by our body that creates
the quality we call "life." There are many forms of
energy used by our bodies: chemical energy, electrical energy,
mechanical energy and electromagnetic energy. This article will
analyze the form of energy called electrical energy or electricity.
It will also describe how substances obtained in our diets are
responsible in generating this form of energy.
Electricity is a fundamental entity of nature
consisting of negative and positive particles exhibiting attractions
and repulsions. These attractions and repulsions manifest themselves
as movements of these charged particles, or in other words--electrical
current. This form of energy plays a critical role in the proper
function of our body.
The key players in creating the electric energy
within our body are structures called ions. An ion is an atom
or group of atoms carrying an electric charge by virtue of having
gained or lost one or more valence electrons. Valence electrons
are those electrons in the outer ring of electrons orbiting the
nucleus of the atom. Ions may exist in solid, liquid, or gaseous
environments, although those in liquid are more common and familiar.
Most ionic compounds fall in the category of chemicals called
salts.
Ions existing in a liquid state are electrolytes.
An electrolyte is any compound that, in solution, conducts electricity
and is decomposed or electrolyzed by the electricity. This form
of compound is ionizable in solution.
Electrolytes, or in other words compounds
that are ionizable in solution, play an essential role in many
body functions. Cells create electrical energy as ions move from
the solutions inside the cells of our body to the solutions outside
the cells. This form of energy is a staple in the normal function
of man body systems. For example, the nervous system uses electrical
energy, termed nerve impulses, to transmit messages from one cell
in the body to another cell in the body. This manifests as muscle
movement, glandular secretion, excretion, temperature regulation,
and even mental thought. Let us analyze, in more detail, the role
of certain ions in some body functions.
In the body, fluids both inside and outside
the cells are electrolyte solutions. This means they are water
suspensions of ions. The electrolyte solutions both inside and
outside the cells contain equal amounts of positive (cations)
and negative (anions) ions making the body as a whole electrically
neutral (see Table 1). The limiting boundary of the cell, the
cell membrane, separates these ionic solutions.
Generally, a very small excess of anions accumulates
immediately inside the cell membrane along its inner surface,
and an equal number of cations accumulates immediately outside
the cell membrane. This is the resting state of the cell. This
difference in ion concentration on the adjacent surfaces of the
cell membrane creates an electrical energy potential or electrochemical
gradient. This is very similar to a battery where one end has
a larger concentration of positively charged particles and the
other end a greater concentration of negatively charged particles.
Completing the circuit by connecting the ends of the battery,
allows charged particles to move between the two ends creating
energy as an electrical current. A similar energy source arises
in the body as charged ions move across the cell membrane.
In our bodies, the nervous and muscular systems
use the electrolyte properties of ionic sodium and potassium,
assisted by lesser trace elements ( e.g. copper) to generate currents
across the membranes of their cells. This current, or movement
of charged particles, results from the electrochemical gradient
set up across the cell membrane. The electrochemical gradient
sets up the two types of movement that produce the current. The
chemical gradient results in the passive movement of ions from
a region of higher concentration to a region of lower concentration.
The electrical gradient creates a movement of ions of one charge
to an area of ions of the opposite charge. The result of this
current is the transmission of nerve impulses and the contraction
of muscle tissue.
The ionic particles of the nervous impulse
can be visualized in the following simplified process. Neurons,
the conducting cells of the nervous system, communicate by generating
and propagating action potentials. An action potential is an abrupt
pulse-like change in the positive-negative charge differential
on either side of the nerve cell membrane. This results in a change
of the resting potential of the cell. This can be caused by any
factor that suddenly increases the permeability of the cell membrane
for positively charged sodium ions. This movement of ions results
in a flow of charged particles into and out of the cell, creating
an electrical current. The replication of this process to adjacent
areas of the cell membrane forms the electrical message, or nervous
impulse, that moves along the nerve cell toward another cell in
the body. This propagated action potential then becomes the energy
source that initiates body functions ranging from muscle contraction
to creative thought.
Ions, as we can see, play an important role
in the body. Calcium, potassium, sodium, chloride, and copper
ions are some key ions that participate in the body's electrical
events. Potassium is the major positive ion inside the cell. Sodium
is the major positive ion found in the fluid outside the cell.
Ionic chlorine is the most abundant negative ion. Imbalances of
any of these ions or certain trace ions in the body or inhibition
of sodium ion transport across the cell membranes can lead to
dysfunction in the conduction of electrical messages. This dysfunction
quickly leads to a general body disturbance and loss of ability
to maintain somewhat stable internal conditions. We then come
back to the problem we faced when we started this article saying,
"We just do not have enough energy."
| Table 1 -- Elements of the Human Body
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| Element
| % of Body
| Functional Significance
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| Oxygen |
65.0
| A major contributor to both organic and inorganic molecules; as a gas it is necessary for the production of cellular energy.
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| Carbon |
18.5
| The main component of all organic molecules, i.e. carbohydrates, lipids, proteins, and nucleic acids.
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| Hydrogen |
10.0
| Another component of all organic molecules; in its ionic form it is influential on the pH of body fluids.
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| Nitrogen |
3.0
| An important structural component of all genetic material (nucleic acids).
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| Calcium |
1.2
| A building block of bones and teeth; its ionic form is essential in muscle contraction, impulse conduction in nerves, and blood clotting.
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| Phosphorus
| 1.0
| Joins calcium to contribute to bone crystalline structure; present in nucleic acids and ATP.
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| Potassium
| 0.4
| Its ionic form is the major cation (positive ions) in cells; necessary for conduction of nerve impulses and muscle contraction.
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| Sulfur |
0.3
| Important component of muscle proteins
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| Sodium |
0.2
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| Chlorine |
0.2
| In ionic form is the most abundant anion (negative ion) outside the cell.
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| Magnesium
| 0.1
| Found in bone and plays an important assisting role in many metabolic functions.
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| Iodine |
0.1
| Required in thyroid hormones which are the body's main metabolic hormones.
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| Iron |
0.1
| Basic building block of the hemoglobin molecule which is a major transporter of oxygen in body.
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| The following elements are referred to as trace elements because they are required to in very minute amounts. They are, however, important elements found as part of enzymes or are required for enzyme activation.
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| Chromium |
| Promotes glucose metabolism; helps regulate blood sugar.
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| Cobalt |
| Promotes normal red-blood cell formation.
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| Copper |
| Promotes normal red-blood cell formation; acts as a catalyst in storage and formation; acts as a catalyst in storage and release of iron to form hemoglobin; promotes connective tissue formation and central nervous system function.
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| Fluorine |
| Prevents dental caries
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| Manganese
| | Promotes normal growth and development; promotes cell function; helps many body enzymes generate energy.
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| Molybedenum
| | Promotes normal growth and development and cell function.
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| Selenium |
| Complements Vitamin E to act as an efficient anti-oxidant.
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| Vanadium |
| Plays role in metabolism of bones and teeth.
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| Zinc |
| Maintains normal taste and smell; aids wound healing; helps synthesize DNA and RNA.
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